In 1946, Italian immigrant Daniel Biasone sent a $5,000 check to the National Basketball League offices in Chicago, and the Syracuse Nationals became the largely Midwest-based league's easternmost team, based in the Upstate New York city of Syracuse.[2] The Syracuse Nationals began play in the NBL in the same year professional basketball was finally gaining some legitimacy with the rival Basketball Association of America that was based in large cities like New York and Philadelphia. While in the NBL with teams largely consisting of small Midwestern towns, the Nationals put together a 21–23 record, finishing in 4th place. In the playoffs, the Nats would be beaten by the fellow upstate neighbor Rochester Royals in 4 games.

The playoff overtime loss on March 26, 1963, would prove to be the last game for the Syracuse Nationals, as investors Irv Kosloff and Ike Richman purchased the team from Danny Biasone moving the team to Philadelphia, filling the void left by the Warriors. Syracuse was the last of the medium-sized cities housing an NBA team, but by then it was apparent that central New York was no longer large enough to support it. The NBA thus returned to Philadelphia one year after the Warriors had left for San Francisco. A contest was held to decide on a new name for the team.  The winning name, chosen by Walter Stalberg, was the "76ers".[5][6]  Newspaper writers liked the name because it was easily shortened to "Sixers" in headlines.  The shorter name was quickly accepted by the team for marketing purposes, and for most of the last half-century "76ers" and "Sixers" have been officially interchangeable.